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IMMUNOGLOBULIN J-CHAINS
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DeCS
Descriptor
English
:
Immunoglobulin J-Chains
Descriptor
Spanish
:
Cadenas J de Inmunoglobulina
Descriptor
Portuguese
:
Cadeias J de Imunoglobulina
Synonyms
English
:
J-Chains, Immunoglobulin
Tree Number:
D12.776.124.486.485.705.625
D12.776.124.790.651.705.625
D12.776.377.715.548.705.625
Definition
English
:
A 15 kD "joining" peptide that forms one of the linkages between monomers of
IMMUNOGLOBULIN A
or
IMMUNOGLOBULIN M
in the formation of polymeric
immunoglobulins
. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric
immunoglobulins
to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their
transcytosis
to the lumen. It is distinguished from the
IMMUNOGLOBULIN JOINING REGION
which is part of the
IMMUNOGLOBULIN VARIABLE REGION
of the immunoglobulin light and heavy chains.
Pharmacological Action:
Immunologic Factors
See Related
English
:
Immunoglobulin A
Immunoglobulin M
History Note
English
:
2006 (1974)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30363
Unique Identifier:
D007144
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS